MS-Align+

Summary

Because of advances in protein separation and mass spectrometry, top-down mass spectrometry moved from analyzing single proteins to analyzing complex samples and identifying hundreds and even thousands of proteins. However, computational tools for database search of top-down spectra against protein databases are still in their infancy. MS-Align+ is a fast algorithm for top-down protein identification based on spectral alignment that enables searches for unexpected post-translational modifications.