Projects, Collaborations and Community
Driving Biological Projects
From Monoclonal to Polyclonal Antibody Sequencing
Primary Collaborator(s): Jennie Lill
Collaborator(s) Institution: Dept. of Protein Chemistry, Genentech
CCMS Personnel: Vineet Bafna, Nuno Bandeira, Pavel Pevzner
A Systems Approach towards the Therapeutic Modulation of the Acetylome
Primary Collaborator(s): Anne-Claude Gingras
Collaborator(s) Institution: Samuel Lunenfeld Institute
CCMS Personnel: Vineet Bafna, Nuno Bandeira, Pavel Pevzner
Interspecies chemical interactions
Primary Collaborator(s): Kit Pogliano, Pieter Dorrestein
Collaborator(s) Institution: Division of Biological Sciences at UCSD, School of Pharmacy at UCSD
CCMS Personnel: Nuno Bandeira, Pavel Pevzner
Proteogenomic Development of Breast Cancer Vaccines
Primary Collaborator(s): Paul Spellman (Oregon Health Sciences University), Peter Lee (City of Hope Hospital), Jill Slansky (University of Colorado)
CCMS Personnel: Vineet Bafna, Nuno Bandeira
Proteogenomics approach to studies of polybacterial infections
Primary Collaborator(s): Jeffrey McLean
Collaborator(s) Institution: J. Craig Venter Institute
CCMS Personnel: Pavel Pevzner
Protein-Protein Interactions and PTMs in Cataractous Lens
Primary Collaborator(s): Larry David
Collaborator(s) Institution: Oregon Health and Sciences University
CCMS Personnel: Vineet Bafna, Nuno Bandeira, Pavel Pevzner
Proteomic Biomarkers for Drug Toxicity in Cancer Patients
Primary Collaborator(s): Emily Chen, Dawn Hershman
Collaborator(s) Institution: Columbia University Mecial Center
CCMS Personnel: Vineet Bafna, Nuno Bandeira, Pavel Pevzner
Discovery of Lantibiotics
Primary Collaborator(s): Willem (Wilfred) van der Donk
Collaborator(s) Institution: Department of Chemistry, University of Illinois at Urbana-Champaign, Howard Hughes Medical Institute
CCMS Personnel: Nuno Bandeira, Pavel Pevzner
Clinical Cancer Proteogenomics
Primary Collaborator(s): Richard Smith, Karin Rodland, Sam Payne
Collaborator(s) Institution: PNNL
CCMS Personnel: Vineet Bafna
Unraveling the Combinatorial Histone Code in Human Diseases
Primary Collaborator(s): Benjamin Garcia
Collaborator(s) Institution: Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania
CCMS Personnel: Vineet Bafna, Pavel Pevzner
projects, Collaborations, and Community
Accomplished Collaborations & Service Projects
Primary Collaborator(s): Richard Smith (PNNL) Collaborator(s) Institution: PNNL CCMS Personnel: Pavel Pevzner, Nuno Bandeira, Ari Frank Project Dates: 2008-2012 Publications: Clustering millions of tandem mass spectra.
Primary Collaborator(s): Jeff Smith (Burnham), Andrei Osterman (Burnham).
Collaborator(s) Institution: Burnham
CCMS Personnel: Pavel Pevzner, Nitin Gupta
Project Dates: 2010-2012
Primary Collaborator(s): Javier Satulovsky (Agilent Technologies), Roman Zubarev (Karolinska Institute).
Collaborator(s) Institution: Agilent Technologies
CCMS Personnel: Pavel Pevzner, Sangtae Kim, Ilya Kolykhmatov
Project Dates: 2009-2011
Primary Collaborator(s): Eduardo Macagno (UCSD), Theodore Alexandrov (University of Bremen), Michel Salzet (Universite de Lille), Isabelle Fournier (Universite de Lille). Collaborator(s) Institution: UCSD CCMS Personnel: Vineet Bafna, Jocelyne Bruand Project Dates: 2008-2012 Publications: AMASS: algorithm for MSI analysis by semi-supervised segmentationPublications:
Primary Collaborator(s): Eduardo Macagno (UCSD), Michel Salzet (Universite de Lille), Isabelle Fournier (Universite de Lille)
Collaborator(s) Institution: UCSD
CCMS Personnel: Vineet Bafna, Nuno Bandeira, Jocelyne Bruand
Project Dates: 2008-2012
Primary Collaborator(s): Julia Laskin (PNNL).
Collaborator(s) Institution: PNNL
CCMS Personnel: Vineet Bafna, Jocelyne Bruand, Doruk Beyter
Project Dates: 2008-2012
Publications:
Correlating Leech Proteogenomics with MS Imaging
Primary Collaborator(s): Terry Gaasterland (UCSD), Eduardo Macagno (UCSD)
Collaborator(s) Institution: UCSD
CCMS Personnel: Vineet Bafna, Jocelyne Bruand, Sunghee Woo
Project Dates: 2008-2012
Sequencing Cyclic Peptides by Multistage Mass Spectrometry
Primary Collaborator(s): Pieter Dorrestein (UCSD) Collaborator(s) Institution: UCSD CCMS Personnel: Pavel Pevzner, Hosein Mohimani Project Dates: 2011-2012 Publications: Sequencing cyclic peptides by multistage mass spectrometry.Publications:
http://www.ncbi.nlm.nih.gov/pubmed/22414154
Primary Collaborator(s): William Fenical (UCSD). Collaborator(s) Institution: UCSD CCMS Personnel: Pavel Pevzner, Pieter Dorrestein, Hosein Mohimani Project Dates: Oct. 2011 – June, 2013 Publications: Multiplex de novo sequencing of peptide antibiotics.Publications:
iPRG 2011: Identification of Electron Transfer Dissociation (ETD) Mass Spectra
Primary Collaborator(s): ABRF Proteome Informatics Research Group (iPRG)
Collaborator(s) Institution: ABRF Proteome Informatics Research Group (iPRG)
CCMS Personnel: Nuno Bandeira
Project Dates: Oct 2010 - Feb 2011
iPRG 2013: Using RNA-Seq Data to Refine Proteomic Data Analysis
Primary Collaborator(s): ABRF Proteome Informatics Research Group (iPRG)
Collaborator(s) Institution: ABRF Proteome Informatics Research Group (iPRG)
CCMS Personnel: Nuno Bandeira
Project Dates: Oct 2012 - Feb 2013
Open data formats for proteomics: mzIdentML support in MS-GF
Primary Collaborator(s): Andrew Jones, University of Liverpool, UK
Collaborator(s) Institution: University of Liverpool, UK
CCMS Personnel: Nuno Bandeira, Sangtae Kim
Project Dates: Jan 2012- June 2012
CPTAC integration of MS-GF and False Localization Rates
Primary Collaborator(s): Paul Rudnick, NIST
Collaborator(s) Institution: NIST
CCMS Personnel: Nuno Bandeira, Sangtae Kim, June Snedecor
Project Dates: Jan 2013- July 2013
False localization rates for PTM site assignments
Primary Collaborator(s): Huilin Zhou (UCSD)
Collaborator(s) Institution: UCSD
CCMS Personnel: Vineet Bafna, Nuno Bandeira, June Snedecor
Project Dates: 2010-Current
Generating peptide sequence tags for top-down spectra
Primary Collaborator(s): Kira Vyatkina (St. Petersburg Academic University), Lijiljana Pasa-Tolic (PNNL)
Collaborator(s) Institution: St. Petersburg Academic University, PNNL
CCMS Personnel: Pavel Pevzner, Xiaowen Liu, Stefano Bonissone
Project Dates: 2012-Current
Optimizing antibody proteogenomics pipeline at Genentech.
Primary Collaborator(s): Jennie Lill (Genentech) CCMS Personnel: Nuno Bandeira, Vineet Bafna, Adrian Guthals, Natalie Castellana, Stefano Bonissone Project Dates: 2007 - Current Publications: PMID:20164058Publications: PMID:21268269
New approach for identification of SUMOylated peptides.
Primary Collaborator(s): Jennie Lill (Genentech) CCMS Personnel: Nuno Bandeira, Jian Wang Project Dates: Aug 2012 - Current Publications: PMID:24437954
Combining MS and NGS for analyzing brain proteome.
Primary Collaborator(s): Philip Khaitovich (Max Planck Institute, Shanghai)
CCMS Personnel: Pavel Pevzner, Boyko Kakaradov, Stefano Bonissone
Project Dates: 2011 - Current
Discovery and phasing of SNPs using bottom-up and top-down MS.
Primary Collaborator(s): David Herold (VA Hospital, San Diego)
CCMS Personnel: Nuno Bandeira, June Snedecor
Project Dates: 2012 – Current
High throughput identification of top-down spectra.
Primary Collaborator(s): Julian Whitelegge (UCLA), David R. Goodlett (University of Washington), Richard D. Smith (PNNL), Lijiljana Pasa-Tolic(PNNL) CCMS Personnel: Vineet Bafna, Pavel Pevzner, Xiaowen Liu, Stefano Bonissone Project Dates: Aug 2010 - Current Publications: PMID:22027200Publications: PMID:24188097Publications: PMID:23720318Publications: PMID:20855543
Improving signal peptide prediction via mass spectrometry.
Primary Collaborator(s): Dmitry Frishman (Technical University of Munich), Sam Payne (PNNL) CCMS Personnel: Pavel Pevzner, Stefano Bonissone Project Dates: Sep 2011 - Current Publications: PMID:23556536
Learning functions of NRP and RiPP biosynthetic enzymes by MS.
Primary Collaborator(s): Marnix Medama (University of Groningen)
CCMS Personnel: Pavel Pevzner, Pieter Dorrestein, Hosein Mohimani
Project Dates: Jan 2013 - Current
Natural product discovery by MS and genome mining.
Primary Collaborator(s): Pieter Dorrestein (UCSD), Wilfred van der Donk (UIUC)
CCMS Personnel: Pavel Pevzner, Hosein Mohimani, Stefano Bonissone
Project Dates: June 2012 - Current
Publications: Submitted
Dereplication and sequencing of marine non-ribosomal peptides.
Primary Collaborator(s): Pieter Dorrestein (UCSD), William Gerwick (UCSD) and Roger Linington (UCSC) CCMS Personnel: Nuno Bandeira, Pavel Pevzner, Julio Ng, Hosein Mohimani, Stefano Bonissone Project Dates: 2009 - Current Publications: PMID:19413302Publications: PMID:19597502Publications: PMID:20534563Publications: PMID:20805502
Assessing spectrum-spectrum match significance for neuropeptidomics.
Primary Collaborator(s): Pieter Dorrestein (UCSD), Vivian Hook (UCSD) CCMS Personnel: Nuno Bandeira, Mingxun Wang Project Dates: Jan 201 - Current Publications: PMID:23808827
De novo protein sequencing of snake venoms and antibodies.
Primary Collaborator(s): Karl Clauser (Broad Institute), Jennie Lill (Genentech), David Goodlett (U Washington), Toni Koller (SUNY Stony Brook), Olga Haim (Universidade Federal do Parana, Brazil), Richard Valente (Foundation Oswaldo Cruz, Brazil), Kira Vyatkina (Saint Petersburg Academic University), Ljijljana Pasa-Tolic (PNNL) CCMS Personnel: Nuno Bandeira, Vineet Bafna, Pavel Pevzner, Natalie Castellana, Xiaowen Liu, Adrian Guthals, Joao Canhita Project Dates: 2008 – Current Publications: PMID:18785330Publications: PMID:19060866Publications: PMID:22798278Publications: PMID:23679345Publications: PMID:17446555
Optimizing proteogenomics annotation pipeline for very large spectral datasets.
Primary Collaborator(s): Steve Briggs (UCSD), Laurie Smith (UCSD) CCMS Personnel: Vineet Bafna, Natalie Castellana, Sunghee Woo Project Dates: Aug 2008 - Current Publications: PMID:20620248Publications: PMID:19098097Publications: PMID:24248366
Mismatch-tolerant spectral library searches.
Primary Collaborator(s): Emily Chen (Columbia University), Toni Koller (SUNY Stony Brooks)
CCMS Personnel: Nuno Bandeira, Mingxun Wang
Project Dates: Jan 2012 - Current
N-terminal protein processing and N-acetylation.
Primary Collaborator(s): Ralph Bradshaw (UCSF), Margie Romine (PNNL) CCMS Personnel: Pavel A. Pevzner, Stefano Bonissone Project Dates: May 2012 - current Publications: PMID:23001859
Identification of protein-protein interaction using cross-linking.
Primary Collaborator(s): Phil Andrews (U. Michigan)
Collaborator(s) Institution: U. Michigan
CCMS Personnel: Nuno Bandeira, Jian Wang
Project Dates: Aug 2012 – Current
Development of Enosi proteogenomics tool and its integration with EMC storage solutions.
Primary Collaborator(s): Kamil Isaev (EMC)
Collaborator(s) Institution: EMC
CCMS Personnel: Pavel Pevzner, Vineet Bafna, Nuno Bandeira
Project Dates: Sep 2013 - Current
De novo sequencing of unyielding monoclonal antibodies.
Primary Collaborator(s): Michael MacCoss (University of Washington)
Collaborator(s) Institution: University of Washington
CCMS Personnel: Nuno Bandeira, Adrian Guthals
Project Dates: Jan 2013 - Current
Open data formats for proteomics: mzTab format.
Primary Collaborator(s): Juan Vizcaino (European Bioinformatics Institute, UK)
Collaborator(s) Institution: European Bioinformatics Institute, UK
CCMS Personnel: Nuno Bandeira
Project Dates: 2012 - Current
Publications: Submitted
Search for bioactive endogenous peptides using spectral networks.
Primary Collaborator(s): Michael Djordjevic (Australian National University, Canberra, Australia)
Collaborator(s) Institution: Australian National University, Canberra, Australia
CCMS Personnel: Nuno Bandeira, Ming Wang
Project Dates: July 2013 - Current
Cancer proteogenomics.
Primary Collaborator(s): Shiv Nagaraj (Univ. Queensland, Australia)
Collaborator(s) Institution: Univ. Queensland, Australia
CCMS Personnel: Vineet Bafna, Seong Cha
Project Dates: Aug 2012 - Current
MassIVE integration with ProteomeXchange.
Primary Collaborator(s): Henning Hermjakob (European Bioinformatics Institute, UK)
Collaborator(s) Institution: European Bioinformatics Institute, UK
CCMS Personnel: Nuno Bandeira, Jeremy Carver
Project Dates: Aug 2012 - Current
Publications: (Nature Biotech, in press)
C. elegans proteogenomics.
Primary Collaborator(s): Michael MacCoss (University of Washington) Collaborator(s) Institution: University of Washington CCMS Personnel: Vineet Bafna, Sunghee Woo Project Dates: Dec 2012- Current Publications: PMID:23802565
Constructing the mass-spectrometry encyclopedia of neurotransmitters.
Primary Collaborator(s): Vivian Hook (UCSD) CCMS Personnel: Nuno Bandeira, Pavel Pevzner, Jian Wang, Yoona Kim Project Dates: 2009 – Current Publications: PMID:21821666Publications: PMID:20734175Publications: PMID:20704348
Identification of cross-links using top-down mass spectrometry.
Primary Collaborator(s): Ljiljana Pasa-Tolic (PNNL)
CCMS Personnel: Pavel Pevzner, Vineet Bafna, Xiaowen Liu, Stefano Bonissone
Project Dates: Jan 2011- Current
Antibiotics discovery using genome mining in fragmented bacterial datasets.
Primary Collaborator(s): Bill Gerwick (UCSD), Lixin Zhang (Institute for Microbiology, Beijing, China) CCMS Personnel: Pavel Pevzner, Dmitry Brinza, Hosein Mohimani Project Dates: Jan. 2010- Current Publications: PMID:21533272Publications: PMID:21488639Publications: PMID:20534563
Integration of CCMS Proteogenomics tools in the Galaxy-P and BaseSpace platforms.
Primary Collaborator(s): Anne-Francois Lamblin (University of Minnesota), Ilya Chorny (Illumina)
CCMS Personnel: Vineet Bafna, Sunghee Woo
Project Dates: Dec 2013- Current
Identification of novel gene structures in model organisms.
Primary Collaborator(s): Akhilesh Pandey
Collaborator(s) Institution: Johns Hopkins University
CCMS Personnel: Vineet Bafna, Sunghee Woo
Project Dates: Aug 2012- Current
Peptide fragmentation models for new enzymes
Primary Collaborator(s): Elizabeth Komives Collaborator(s) Institution: UCSD CCMS Personnel: Nuno Bandeira, Pavel Pevzner, Sangtae Kim, Adrian Guthals Publications: PMID: 24425750
De novo protein sequencing using top-down MS
Primary Collaborator(s): Ljiljana Pasa-Tolic (PNNL); Kira Vyatkina (St. Petersburg Academic University), Leonard Dekker (Erasmus Medical Center)
Collaborator(s) Institution: PNNL, St. Petersburg Academic University, Erasmus Medical Center
CCMS Personnel: Vineet Bafna, Pavel Pevzner, Xiaowen Liu, Stefano Bonissone
Project Dates: 2013-Current
Publications: submitted
Open data formats for proteomics data: mzIdentML support in MS-GF+
Primary Collaborator(s): Andrew Jones
Collaborator(s) Institution: University of Liverpool, UK
CCMS Personnel: Santae Kim
Project Dates: 2012
iPRG 2013: Using RNA-Seq Data to Refine Proteomic Data Analysis
Collaborator(s) Institution: ABRF Proteome Informatics Research Group (iPRG) CCMS Personnel: Nuno Bandeira Project Dates: Oct 2012 - Feb 2013 Publications: Study Results
iPRG 2012: A Study on Detecting Modified Peptides in a Complex Mixture
Collaborator(s) Institution: ABRF Proteome Informatics Research Group (iPRG) CCMS Personnel: Nuno Bandeira Project Dates: Oct 2011 - Feb 2012 Publications: PMID: 24187338Publications: Study Results
iPRG 2011: Identification of Electron Transfer Dissociation (ETD) Mass Spectra
Collaborator(s) Institution: ABRF Proteome Informatics Research Group (iPRG) CCMS Personnel: Nuno Bandeira Project Dates: Oct 2010 - Feb 2011 Publications: Study Results
Scoring models and de novo sequencing for neutron-encoded MS
Primary Collaborator(s): Joshua Coon Collaborator(s) Institution: University of Wisconsin CCMS Personnel: Nuno Bandeira, Adiean Guthals Project Dates: Aug 2013 - Dec 2013 Publications: PMID: 24043425 Funding: NIGMS GM080148, NHGRI 5T32HG002760, NLM T15LM007359, NSF/NIH T32GM008505
MS-GF+ scoring models for new enzymes
Primary Collaborator(s): Elizabeth Komives
Collaborator(s) Institution: UCSD
CCMS Personnel: Nuno Bandeira, Sangtae Kim, Adrian Guthals