Molecular networks

Contacts

Mingxun Wang [miw023 at cs.ucsd.edu]

Summary

Similarly to comparative genomics’ study of how changes in genomic features can relate to phenotypic evolution, molecular networking analyzes how changes in MS/MS fragmentation can inform about differences in compound structure. Thus for spectra in a dataset, similar MS/MS spectra are found and represented as a network. This network is a powerful organization and visualization tool as it allows spectra to be grouped together in chemical classes, giving researchers a much more guided approach to identify novel molecular. The use of molecular networking has allowed for orders of magnitude gains in speedup of small molecule compound identification.

figMolSpecNets

Documentation

Molecular Networking Documentation

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Publications

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking Mingxun Wang, Jeremy J Carver, [...], Pieter C Dorrestein, Nuno Bandeira. "Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking." Nature biotechnology 34.8 (2016): 828-837
Mass spectral molecular networking of living microbial colonies. Watrous J, Roach P, Alexandrov T, Heath BS, Yang JY, Kersten RD, van der Voort M, Pogliano K, Gross H, Raaijmakers JM, Moore BS, Laskin J, Bandeira N, Dorrestein PC. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1743-52. doi: 10.1073/pnas.1203689109. Epub 2012 May 14.
Interkingdom metabolic transformations captured by microbial imaging mass spectrometry. Moree WJ, Phelan VV, Wu CH, Bandeira N, Cornett DS, Duggan BM, Dorrestein PC. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13811-6. doi: 10.1073/pnas.1206855109.
MS/MS networking guided analysis of molecule and gene cluster families. Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X, Gavilan RG, Aparicio M, Atencio L, Jackson C, Ballesteros J, Sanchez J, Watrous JD, Phelan VV, van de Wiel C, Kersten RD, Mehnaz S, De Mot R, Shank EA, Charusanti P, Nagarajan H, Duggan BM, Moore BS, Bandeira N, Palsson BØ, Pogliano K, Gutiérrez M, Dorrestein PC. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2611-20. doi: 10.1073/pnas.1303471110. Epub 2013 Jun 24.